Alpha-Tocopherol Inhibits Tocotrienol Uptake
PuMed.org


Alpha-Tocopherol a Detriment to Tocotrienol Benefits

Japanese researchers have previously shown delta-tocotrienol to be the most potent anti-angiogenic Vitamin E compound. (1, 2)

In a recent study, the same researchers tested the influence of tocopherol on the cytotoxic effects of delta-tocotrienol in human colorectal cancer cells.  Tocopherol, and especially alpha-tocopherol was found to interfere with delta-tocotrienol’s cytotoxic effects.  Further, results indicate that alpha-tocopherol is not only less cytotic to cancer cells, but also reduces the anti-cancer effects of delta-tocotrienol by inhibiting its cellular uptake. (3)

A.C. Grace Company’s UNIQUE E® Tocotrienol is a naturally tocopherol-free tocotrienol derived from the rainforest annatto plant.  Uniquely, UNIQUE E® Tocotrienol provides only the two most potent delta- and gamma-tocotrienol isomers, thus providing maximum tocotrienol benefit.

For information on the benefits provided by Annatto Tocotrienol, watch a recent segment on CNBC with Hugh Downs and Dr. Barrie Tan of American River Nutrition, the supplier of A.C. Grace Company’s UNIQUE E® Tocotrienol.

Watch this TOCOTRIENOL segment.

cnbc_tocotrienols 

Read the PubMed abstract.


References

1.    Shibata, A., et al., delta-Tocotrienol suppresses VEGF induced angiogenesis whereas alpha-tocopherol does not. J Agric Food Chem, 2009. 57(18): p. 8696-704.

2.    Shibata, A., et al., Tumor anti-angiogenic effect and mechanism of action of delta-tocotrienol. Biochem Pharmacol, 2008. 76(3): p. 330-9.

3.    Shibata, A., et al., alpha-Tocopherol attenuates the cytotoxic effect of delta-tocotrienol in human colorectal adenocarcinoma cells. Biochem Biophys Res Commun.


A.C. Grace Company NOTE: Since the launch of our UNIQUE E® Tocotrienol product in 2008, we have been educating doctors and their patients, health food stores and consumers on the tremendous benefits of high-delta tocotrienol derived from the Annatto Plant in Brazil. This recent study validates what we have known from the beginning – that alpha-tocopherol inhibits the absorption of tocotrienols if taken together! This is great news for many who still have questions about what tocotrienols are and how they can help you in your diet.

Keep in mind that this does not mean that the tocopherol forms of the Vitamin E complex are not effective! A PURE, Natural Mixed Tocopherols Concentrate product HIGH in Gamma-Tocopherol and Alpha-Tocopherol, and including Delta- and Beta-Tocopherol is still recommended as a powerful anti-oxidant and major supporter of the cardiovascular and circulatory system. With 93% of Americans being deficient in Vitamin E, it is very important to maintain a protocol using a GREAT Mixed Tocopherols with your morning meal and Annatto Tocotrienol with your evening meal.

Read about UNIQUE E® Tocotrienol and UNIQUE E® Mixed Tocopherols Concentrate at our website: www.acgrace.com.