Recommended Dosages

UNIQUE E® MIXED TOCOPHEROLS

Dosage Recommendations As Suggested By Our Healthcare Professionals:

General Dosage Rules:

• Maximum dose 6 capsules (2400 I.U.)—more than this is usually wasted.
• Entire dosage to be taken ALL AT ONCE.
• Best effect when dosage is taken WITH a meal.

What about vitamin E and drug interactions?

People using drugs such as blood-thinners, cholesterol medications, blood pressure medications, etc, should always start with 1 capsule and work up to optimum dosage over time as needed. Vitamin E can temporarily increase blood pressure in individuals with high blood pressure—monitoring dosage is required. However, it has been reported that over time vitamin E can actually lower blood pressure in subjects with high blood pressure.

Vitamin E is fat soluble, what about liver toxicity, what level is safe?

Unlike other fat soluble vitamins, vitamin E is NOT accumulated in the liver. This astonishing fact was recently proven in a paper entitled, Vitamin E Trafficking.* The authors report, “the liver does not accumulate ‘toxic’ amounts of vitamin E. Excess vitamin E is not accumulated in the liver, but is excreted, mostly in bile, via a p-glycoprotein (ABCB4)-mediated process.”

Ann. N.Y. Acad. Sci. 1031: 1–’D012 (2004). doi: 10.1196/annals.1331.001 Vitamin E Trafficking Maret G. Trabera, Graham W. Burtonb and Robert L. HamiltoncaLinus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA; bOccell, Inc., Ottawa, Ontario K1B 5B0, Canada; cDepartment of Anatomy, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA

Kappus H, Diplock AT. Tolerance and safety of vitamin E: a toxicological position report. Free Radic Biol Med 1992;13:55–’D074.

Vitamins E and C are safe across a broad range of intakes. Hathcock JN, Azzi A, Blumberg J, Bray T, Dickinson A, Frei B, Jialal I, Johnston CS, Kelly FJ, Kraemer K, Packer L, Parthasarathy S, Sies H, Traber MG. Am J Clin Nutr. 2005 Apr;81(4):736-45.

UNIQUE E® MIXED TOCOPHEROLS OIL

• Follow guidelines for UNIQUE E® Tocopherols softgels above.
• 1/4 teaspoon = 400 I.U. (equivalent to one 700mg softgel capsule).
• Maximum dose 1 1/2 teaspoons (2400 I.U.) — more than this is usually wasted.
• Entire dosage to be taken ALL AT ONCE.
• Best effect when dosage is taken WITH a meal.

• One to two capsules per day.
• Maximum benefits achieved when taken at least 2 hours apart from a Tocopherol product, preferably in the evening.
• Entire dosage to be taken ALL AT ONCE.
• Best effect when dosage is taken WITH a meal.
  
  

Statements in this information sheet have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.